Network Publications

• Gaudioso CM, Mar S, Casper TC, Codden R, Nguyen A, Aaen G, Benson L, Chitnis T, Francisco C, Gorman MP, Goyal MS, Graves J, Greenberg BM, Hart J, Krupp L, Lotze T, Narula S, Pittock SJ, Rensel M, Rodriguez M, Rose J, Schreiner T, Tillema JM, Waldman A, Weinstock-Guttman B, Wheeler Y, Waubant E, Flanagan EP; United States Network of Pediatric Multiple Sclerosis Centers. MOG and AQP4 Antibodies among Children with Multiple Sclerosis and Controls. Ann Neurol. 2023 Feb;93(2):271-284. doi: 10.1002/ana.26502. Epub 2022 Oct 4. PMID: 36088544; PMCID: PMC10576841.
• Pizzolato Umeton R, Waltz M, Aaen GS, Benson L, Gorman M, Goyal M, Graves JS, Harris Y, Krupp L, Lotze TE, Shukla NM, Mar S, Ness J, Rensel M, Schreiner T, Tillema JM, Roalstad S, Rodriguez M, Rose J, Waubant E, Weinstock-Guttman B, Casper C, Chitnis T; US Network of Pediatric MS Centers. Therapeutic Response in Pediatric Neuromyelitis Optica Spectrum Disorder. Neurology. 2023 Feb 28;100(9):e985-e994. doi: 10.1212/WNL.0000000000201625. Epub 2022 Dec 2. PMID: 36460473; PMCID: PMC9990442.
• Krupp LB, Waubant E, Waltz M, Casper TC, Belman A, Wheeler Y, Ness J, Graves J, Gorman M, Benson L, Mar S, Goyal M, Schreiner T, Weinstock-Guttman B, Rodriguez M, Tillema JM, Lotze T, Aaen G, Rensel M, Rose J, Chitinis T, George A, Charvet LE; US Network of Pediatric MS Centers. A new look at cognitive functioning in pediatric MS. Mult Scler. 2023 Jan;29(1):140-149. doi: 10.1177/13524585221123978. Epub 2022 Oct 1. PMID: 36189711.
• Schreiner T, Wilson-Murphy M, Mendelt-Tillema J, Waltz M, Codden R, Benson L, Gorman M, Goyal M, Krupp L, Lotze T, Mar S, Ness J, Rensel M, Roalstad S, Rodriguez M, Rose J, Shukla N, Waubant E, Wheeler Y, Casper TC, Chitnis T. Characteristics of pediatric patients with multiple sclerosis and related disorders infected with SARS-CoV-2. Mult Scler. 2023 Apr;29(4-5):576-584. doi: 10.1177/13524585231151948. Epub 2023 Mar 23. PMID: 36960480; PMCID: PMC10040482.
• Sebastian P, Cherbuin N, Barcellos LF, Roalstad S, Casper C, Hart J, Aaen GS, Krupp L, Benson L, Gorman M, Candee M, Chitnis T, Goyal M, Greenberg B, Mar S, Rodriguez M, Rubin J, Schreiner T, Waldman A, Weinstock-Guttman B, Graves J, Waubant E, Lucas R; US Network of Pediatric Multiple Sclerosis Centers. Association Between Time Spent Outdoors and Risk of Multiple Sclerosis. Neurology. 2022 Jan 18;98(3):e267-e278. doi: 10.1212/WNL.0000000000013045. Epub 2021 Dec 8. PMID: 34880094; PMCID: PMC8792813.
• Nasr Z, Schoeps VA, Ziaei A, Virupakshaiah A, Adams C, Casper TC, Waltz M, Rose J, Rodriguez M, Tillema JM, Chitnis T, Graves JS, Benson L, Rensel M, Krupp L, Waldman AT, Weinstock-Guttman B, Lotze T, Greenberg B, Aaen G, Mar S, Schreiner T, Hart J, Simpson-Yap S, Mesaros C, Barcellos LF, Waubant E. Gene-environment interactions increase the risk of paediatric-onset multiple sclerosis associated with household chemical exposures. J Neurol Neurosurg Psychiatry. 2023 Jul;94(7):518-525. doi: 10.1136/jnnp-2022-330713. Epub 2023 Feb 1. PMID: 36725329; PMCID: PMC10272045.
• Bhise V, Waltz M, Casper TC, Aaen G, Benson L, Chitnis T, Gorman M, Goyal MS, Wheeler Y, Lotze T, Mar S, Rensel M, Abrams A, Rodriguez M, Rose J, Schreiner T, Shukla N, Waubant E, Weinstock-Guttman B, Ness J, Krupp L, Mendelt-Tillema J; U.S. Network of Pediatric Multiple Sclerosis Centers. Silent findings: Examination of asymptomatic demyelination in a pediatric US cohort. Mult Scler Relat Disord. 2023 Mar;71:104573. doi: 10.1016/j.msard.2023.104573. Epub 2023 Feb 18. PMID: 36871372.
• Malani Shukla N, Casper TC, Ness J, Wheeler Y, Chitnis T, Lotze T, Gorman M, Benson L, Weinstock-Guttmann B, Aaen G, Rodriguez M, Tillema JM, Krupp L, Schreiner T, Mar S, Goyal M, Rensel M, Abrams A, Rose J, Waltz M, Liu T, Manlius C, Waubant E; U.S. Network of Pediatric Multiple Sclerosis Centers. Demographic Features and Clinical Course of Patients With Pediatric-Onset Multiple Sclerosis on Newer Disease-Modifying Treatments. Pediatr Neurol. 2023 Aug;145:125-131. doi: 10.1016/j.pediatrneurol.2023.04.020. Epub 2023 Apr 28. PMID: 37348193.
• Horton MK, Shim JE, Wallace A, Graves JS, Aaen G, Greenberg B, Mar S, Wheeler Y, Weinstock-Guttman B, Waldman A, Schreiner T, Rodriguez M, Tillema JM, Chitnis T, Krupp L, Casper TC, Rensel M, Hart J, Quach HL, Quach DL, Schaefer C, Waubant E, Barcellos LF. Rare and low-frequency coding genetic variants contribute to pediatric-onset multiple sclerosis. Mult Scler. 2023 Apr;29(4-5):505-511. doi: 10.1177/13524585221150736. Epub 2023 Feb 8. PMID: 36755464; PMCID: PMC10149552.
• Gambrah-Lyles C, Kannan V, Lotze T, Abrams A, Schreiner T, Rodriguez M, Casper TC, Rose JW, Gorman MP, Chitnis T, Loud S, Wheeler Y, Mar S; US Network of Pediatric MS Centers. Assessing Needs and Perceptions of Research Participation in Pediatric-Onset Multiple Sclerosis: A Multistakeholder Survey. Pediatr Neurol. 2023 Dec 4;151:115-120. doi: 10.1016/j.pediatrneurol.2023.11.019. Epub ahead of print. PMID: 38154238.
• Schoeps VA, Zhou X, Horton MK, Zhu F, McCauley KE, Nasr Z, Virupakshaiah A, Gorman MP, Benson LA, Weinstock-Guttman B, Waldman A, Banwell BL, Bar-Or A, Marrie RA, van Domselaar G, O'Mahony J, Mirza AI, Bernstein CN, Yeh EA, Casper TC, Lynch SV, Tremlett H, Baranzini S, Waubant E; US Network of Pediatric MS Centers. Short-chain fatty acid producers in the gut are associated with pediatric multiple sclerosis onset. Ann Clin Transl Neurol. 2023 Nov 13. doi: 10.1002/acn3.51944. Epub ahead of print. PMID: 37955284.
• Nasr Z, Virupakshaiah A, Schoeps VA, Cherbuin N, Casper TC, Waltz M, Hart J, Rodriguez M, Gorman MP, Benson LA, Chitnis T, Rensel M, Abrams A, Krupp L, Waldman AT, Lotze T, Aaen GS, Mar S, Schreiner T, Wheeler Y, Rose J, Shukla NM, Barcellos LF, Lucas R, Waubant E. Gene-environment interactions and risk of pediatric-onset multiple sclerosis associated with time spent outdoors. Mult Scler Relat Disord. 2023 Dec 8;82:105351. doi: 10.1016/j.msard.2023.105351. Epub ahead of print. PMID: 38141560.
• Krysko K, Waltz M, Chitnis T, et al. Menarche and Relapses in Girls with Pediatric Multiple Sclerosis, Neurology, 2020, 94, 1270
• Ziaei A, Lavery AM, Shao XM, Adams C, Casper TC, Rose J, Candee M, Weinstock-Guttman B, Aaen G, Harris Y, Graves J, Benson L, Gorman M, Rensel M, Mar S, Lotze T, Greenberg B, Chitnis T, Hart J, Waldman AT, Barcellos LF, Waubant E. Gene-environment interactions increase the risk of pediatric-onset multiple sclerosis associated with ozone pollution. Mult Scler. 2022 Jan 8:13524585211069926. doi: 10.1177/13524585211069926. Online ahead of print.PMID: 35000467
• Mandel LA, O'Donnell E, Canenguez K, Castro-Mendoza PB, Lotze T, Waubant E, Weinstock-Guttmann B, Chitnis T. Family Perspectives on Clinical Research for Pediatric Multiple Sclerosis: Enhancing Equity. J Patient Exp. 2021 Sep 15;8:23743735211039319. doi: 10.1177/23743735211039319. PMID: 34541304; PMCID: PMC8447100
• Santoro JD, Kerr LM, Codden R, Casper TC, Greenberg BM, Waubant E, Kong SW, Mandl KD, and Gorman MP, Increased Prevalence of Familial Autoimmune Disease in Children with Opsoclonus-Myoclonus Syndrome. Neurol Neuroimmunol Neuroinflamm Nov 2021, 8 (6) e1079; first published Sep 2021, 2 DOI: 10.1212/NXI.0000000000001079,
• Greenberg BM, Casper TC, Mar SS, Ness JM, Plumb P, Liang S, Goyal M, Weinstock-Guttman B, Rodriguez M, Aaen GS, Belman A, Barcellos LF, Rose JW, Gorman MP, Benson LA, Candee M, Chitnis T, Harris YC, Kahn IL, Roalstad S, Hart J, Lotze TE, Rensel M, Rubin JP, Schreiner TL, Tillema JM, Waldman AT, Krupp K, Graves J, Drake K, Waubant E, Familial History of Autoimmune Disorders Among Pediatric Multiple Sclerosis Patients, Neurol Neuroimmunol Neuroinflamm Sep 2021, 8 (5) e1049; DOI: 10.1212/NXI.0000000000001049
• Gaudioso C, Oo S, Mar S, Hendricks-Ferguson VL, Newland P, Varni JW. PedsQL Multiple Sclerosis Module Domain and Item Development: Qualitative Methods. J Child Neurol. 2021 May 28:8830738211015016. doi: 10.1177/08830738211015016. Epub ahead of print. PMID: 34048290.
• Horton, M.K., McCauley, K., Fadrosh, D., Fujimura, K., Graves, J., Ness, J., Wheeler, Y., Gorman, M.P., Benson, L.A., Weinstock-Guttman, B., Waldman, A., Rodriguez, M., Tillema, J.-M., Krupp, L., Belman, A., Mar, S., Rensel, M., Chitnis, T., Casper, T.C., Rose, J., Hart, J., Shao, X., Tremlett, H., Lynch, S.V., Barcellos, L.F., Waubant, E. and (2021), Gut microbiome is associated with multiple sclerosis activity in children. Ann Clin Transl Neurol. https://doi.org/10.1002/acn3.51441
• Wallach Al, Waltz M, Casper TC, Aaen G, Belman A, Benson L, Chitnis T, Gorman M, Graves J, Harris W, Lotze TE, Mar S, Moodley M, Ness JM, Rensel M, Rodriguez M, Rose JW, Schreiner T, Tillema JM, Waubant E, Weinstock-Guttman B, Charvet L, Krupp LB.Cognitive processing speed in pediatric-onset multiple sclerosis: Baseline characteristics of impairment and prediction of decline. Multiple Sclerosis Journal. 2020;26(14):1938-47
• Krysko KM, Graves JS, Rensel M, et al. Real-World Effectiveness of Initial Disease-Modifying Therapies in Pediatric Multiple Sclerosis. Ann Neurol. 2020;88(1):42-55. doi:10.1002/ana.25737
• Santoro JD, Waltz M, Aaen G, et al. Pediatric Multiple Sclerosis Severity score in a Lare U.S. Cohort [published online ahead of print, 2020 Jul 20]. Neurology. 2020;10.1212/WNL.0000000000010414. doi:10.1212/WNL.0000000000010414
  
• Chitnis T, Aaen G, Belman A. et al, Improved relapse recovery in pediatric compared to adult multiple sclerosis, Brain, Volume 143, Issue 9, September 2020, Pages 2733–2741, https://doi.org/10.1093/brain/awaa199
• Graves J, Barcellos B, Krupp L, et al. Vitamin D genes influence MS relapses in children. Multiple Sclerosis. 2019 May 13.
• Rhead B, Shao X, Graves JS, et al. miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS. Ann Clin Transl Neurol. 2019 May 15;6(6):1053-1061.
• Chi C, Shao X, Rhead B, et al. Admixture mapping reveals evidence of differential multiple sclerosis risk by genetic ancestry. PLoS Genet 15(1):1007808.
• Aaen G, Waltz M, Vargas W, et al. Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis. J Child Neurol. DOI: 10.1177/0883073818815041 Epub 2018 Dec 17
• Krysko K, Graves J, Rensel M, et al. Use of newer disease-modifying therapies in pediatric multiple sclerosis in the US. Neurology. Epub 2018 Oct 17
• Mar S, Liang S, Waltz M, Casper T, et al. Several Household Chemical Exposures are associated with Pediatric-Onset Multiple Sclerosis. Annals of Clinical and Translational Neurology. Epub 2018 Oct 09
• Lavery A, Waldman A, Casper T, et al. Urban air quality and associations with pediatric multiple sclerosis. Annals of Clinical and Translational Neurology. Epub 2018 Sep 27
• Nourbakhsh B, Rutatangwa A, Waltz M, et al. Heterogeneity in association of remote herpesvirus infections and pediatric MS. Annals of Clinical and Translational Neurology. Epub 2018 Sep 17
• Pakpoor J, Seminatore B, Graves J, et al. Dietary factors and pediatric multiple sclerosis: a case-control study. Multiple Sclerosis. 2018 Jul;24(8):1067–1076.
• Suleiman L, Waubant E, Aaen G, et al. Early infectious exposures are not associated with increased risk of pediatric-onset multiple sclerosis. Mult Scler Relat Disord. 2018 May;22:103-107. doi: 10.1016/j.msard.2018.03.015. Epub 2018 Mar 26
• Azary S, Schreiner T, Graves J, et al. Contribution of dietary intake to relapse rate in early paediatric multiple sclerosis. J Neurol Neurosurg Psychiatry. 2018 Jan;89(1):28–33.
• Lavery A, Waldman A, Casper T, et al. Examining the contributions of environmental quality to pediatric multiple sclerosis. Multiple Sclerosis and Related Disorders. 2017 Nov;18:164–169.
• Waubant E, Lotze T. Pediatric Demyelinating Diseases of the Central Nervous System and Their Mimics. Switzerland: Springer International Publishing; 2017.
• Gianfrancesco M, Stridh P, Shao X, Rhead B, Graves J, et al. Genetic risk factors for pediatric-onset multiple sclerosis. Multiple Sclerosis. 2017 Oct 1
• Graves J, Chitnis T, Weinstock-Guttman B, et al. Maternal and Perinatal Exposures Are Associated With Risk for Pediatric-Onset Multiple Sclerosis. Pediatrics. 2017 Apr;139(4).
• Gianfrancesco M, Stridh P, Rhead B, et al. Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS. Neurology. 2017 Apr25;88(17):1623–1629. 
• Bourne T,Waltz M, Casper T, et al. Evaluating the association of allergies with multiple sclerosis susceptibility risk and disease activity in a pediatric population. J Neurol Sci. 2017 Apr15;375:371–375.
• Chitnis T, Graves J, Weinstock-Guttman B, et al. Distinct effects of obesity and puberty on risk and age at onset of pediatric MS. Annals of Clinical and Translational Neurology. 2016;3(12):897–907. 
• Tremlett H, Fadrosh D, Faruqi A, et al. Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls. BMC Neurol. 2016;16(1):182.
• Belman A, Krupp L, Olsen C, et al. Characteristics of Children and Adolescents With Multiple Sclerosis. Pediatrics. 2016;138(1).
• Nourbakhsh B, Graves J, Casper T, et al. Dietary salt intake and time to relapse in paediatric multiple sclerosis. J Neurol Neurosurg Psychiatry. 2016;87(12):1350–1353.     
• Tremlett H, Fadrosh D, Faruqi A, et al. Gut microbiota in early pediatric multiple sclerosis: a case-control study. Eur J Neurol. 2016;23(8):1308–1321.
• McDonald J, Graves J,Waldman A, et al. A case-control study of dietary salt intake in pediatric-onset multiple sclerosis. Multiple Sclerosis and Related Disorders. 2016;6:87–92.
• Tremlett H, Fadrosh D, Faruqi A, et al. Gut microbiota composition and relapse risk in pediatric MS: A pilot study. J Neurol Sci. 2016;363:153–157. 
• Graves J, Barcellos L, Shao X, et al. Genetic predictors of relapse rate in pediatric MS. Multiple Sclerosis. 2016;22(12):1528–1535.
• Chitnis T, Ness J, Krupp L, et al. Clinical features of neuromyelitis optica in children: US Network of Pediatric MS Centers report. Neurology. 2016;86(3):245–252.
• Graves J, Grandhe S, Weinfurtner K, Krupp L, Belman A, Chitnis T, Ness J, Weinstock-Guttman B, Gorman M, Patterson M, Rodriguez M, Lotze T, Aaen G, Mowry EM, Rose JW, Simmons T, Casper TC, James J, Waubant E; Protective environmental factors for neuromyelitis optica. For the US Network of Pediatric Multiple Sclerosis Centers. Neurology. 2014 Oct 22. 
• Casper TC, Rose JW, Roalstad S, Waubant E, Aaen G, Belman A, Chitnis T, Gorman M, Krupp L, Lotze TE, Ness J, Patterson M, Rodriguez M, Weinstock-Guttman B, Browning B, Graves J, Tillema JM, Benson L, Harris Y; The US Network of Pediatric Multiple Sclerosis Centers: Development, Progress, and Next Steps. J Child Neurol. 2014 Sep 30.
• Charvet LE, O'Donnell EH, Belman AL, Chitnis T, Ness JM, Parrish J, Patterson M, Rodriguez M, Waubant E, Weinstock-Guttman B, Krupp LB. Longitudinal evaluation of cognitive functioning in pediatric multiple sclerosis: report from the US Pediatric Multiple Sclerosis Network. Mult Scler. 2014 Apr9
• Charvet L, Cleary R, Vazquez K, Belman A, Krupp L; on behalf of the US Network for Pediatric MS. Social cognition in pediatric-onset multiple sclerosis (MS). Mult Scler. 2014 Mar 19.
• Chitnis T, Guttmann CR, Zaitsev A, Musallam A, Weinstock-Guttmann B, Yeh A, Rodriguez M, Ness J, Gorman M, Healy BC, Kuntz N, Chabas D, Strober JB, Waubant E, Krupp L, Pelletier D, Erickson B, Bergsland N, Zivadinov R. Quantitative MRI analysis in children with multiple sclerosis: a multicenter feasibility pilot study. BMC Neurol. 2013 Nov 13;13(1):173.
• Julian L, Serafin D, Charvet L, Ackerson J, Benedict R, Braaten E, et al. Cognitive impairment occurs early in pediatric multiple sclerosis: Results from a US network. Journal of Child Neurology. 2013;28(1):102–107.
• Waldman AT, Gorman MP, Rensel MR, Austin TE, Hertz DP, Kuntz NL; Network of Pediatric Multiple Sclerosis Centers of Excellence of National Multiple Sclerosis Society. Management of pediatric central nervous system demyelinating disorders: consensus of United States neurologists. J Child Neurol. 2011 Jun;26(6):675-82.
• Yeh EA, Waubant E, Krupp LB, Ness J, Chitnis T, Kuntz N, Ramanathan M, Belman A, Chabas D, Gorman MP, Rodriguez M, Rinker JR 2nd, Weinstock-Guttman B; National Network of Pediatric MS Centers of Excellence. Multiple sclerosis therapies in pediatric patients with refractory multiple sclerosis. Archives of neurology 2011;68:437-444.
• Waubant E, Mowry EM, Krupp L, Chitnis T, Yeh EA, Kuntz N, Ness J, Chabas D, Strover H, McDonald J, Belman A, Milazzo M, Gorman M, Weinstock-Guttman B, Rodriguez M, Oksenberg JR, James JA; US Pediatric MS Network. Common viruses associated with lower pediatric multiple sclerosis risk. Neurology 2011;76:1989-1995.
• Chitnis T, Krupp L, Yeh A, Rubin J, Kuntz N, Strober JB, Chabas D, Weinstock-Guttmann B, Ness J, Rodriguez M, Waubant E. Pediatric multiple sclerosis. Neurol Clin. 2011 May;29(2):481-505.
• Kuntz NL, Chabas D, Weinstock-Guttman B, Chitnis T, Yeh EA, Krupp L, Ness J, Rodriguez M, Waubant E; Network of US Pediatric Multiple Sclerosis Centers. Treatment of multiple sclerosis in children and adolescents. Expert Opin Pharmacother. 2010 Mar;11(4):505-20.
• Chabas D, Ness J, Belman A, Yeh EA, Kuntz N, Gorman MP, Strober JB, De Kouchkovsky I, McCulloch C, Chitnis T, Rodriguez M, Weinstock-Guttman B, Krupp LB, Waubant E; US Network of Pediatric MS Centers of Excellence. Younger children with MS have a distinct CSF inflammatory profile at disease onset. Neurology. 2010 Feb 2;74(5):399-405.
• Yeh EA, Chitnis T, Krupp L, Ness J, Chabas D, Kuntz N, Waubant E; US Network of Pediatric Multiple Sclerosis Centers of Excellence. Pediatric multiple sclerosis. Nat Rev Neurol. 2009 Nov;5(11):621-31. 

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